Peripheral mediatory mechanisms of behaviorally conditioned immunosuppression by cyclosporin A
نویسنده
چکیده
I would like to take the opportunity to thank the members of the dissertation committee: First and foremost, my deepest thanks go to Professor Manfred Schedlowski for giving me the opportunity to conduct the research for my dissertation in his laboratory. I am very thankful for the daily supervision, guidance and support under awkward circumstances, as well as for his trust in me throughout these years. He provided me with a solid foundation which will enable me to pursue my scientific goals. for taking the time to read my thesis and for agreeing to be a member of my exam committee. I am extremely grateful to Professor Joram Feldon for sharing his neurobiological expertise with me, for supervising the neurobiological projects included in my thesis and for taking over the responsibility as first examiner of the present thesis as well as for providing animal husbandry and care in his facilities. My thanks also go to all the present and past members of the Laboratory of Psychology and Behavioural Immunobiology, ETH Zurich: I am indebted to Dr. In the last three years they have probably got to know me better than I know myself. Their contribution with different kinds of expertise was indispensable for the realization of the present thesis. I would also like to express my sincere thanks to them for running and assisting the immunological and neurobiological assays, for the long and for constantly providing new motivation and a feeling of well-being. The project would never have achieved such scope without their help. I would also like to express my sincere thanks to Professor C. Heijnen and Dr. Annemieke Kavellars for planning and assisting the immunological assays in their laboratory in Utrecht. Their contribution, especially to the immunological studies, was indispensable for the realization of the present thesis. I would also like to acknowledge Hanneke Willemen's excellent assistance with the Western Blots and the immuno-precipitation. Schwendener, and Mary Muhia for joining me in many interesting discussions about the exciting world of neuro-psycho-endocrino-immuno-biological functions and for being good buddies throughout the past few years. A special " thank you " is due to Dr. Dirk Hanebuth for his constant supply of food, music, energy, motivation and other help. β β β β-adreneroceptor stimulation inhibits calcineurin activity in T lymphocytes via a PKA
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Neural substrates for behaviorally conditioned immunosuppression in the rat.
We have previously demonstrated behaviorally conditioned immunosuppression using cyclosporin A as an unconditioned stimulus and saccharin as a conditioned stimulus. In the current study, we examined the central processing of this phenomenon generating excitotoxic lesions before and after acquisition to discriminate between learning and memory processes. Three different brain areas were analyzed...
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